Sunday, May 3, 2009
Life As We Know It Nearly Created in Lab
One of life's greatest mysteries is how it began. Scientists have pinned it down to roughly this:
Some chemical reactions occurred about 4 billion years ago — perhaps in a primordial tidal soup or maybe with help of volcanoes or possibly at the bottom of the sea or between the mica sheets — to create biology.
Now scientists have created something in the lab that is tantalizingly close to what might have happened.
It's not life, they stress, but it certainly gives the science community a whole new data set to chew on.
The researchers, at the Scripps Research Institute in La Jolla, Calif., created molecules that self-replicate and even evolve and compete to win or lose. If that sounds exactly like life, read on to learn the controversial and thin distinction.
Know your RNA
To understand the remarkable breakthrough, detailed Jan. 8 in the early online edition of the journal Science, you have to know a little about molecules called RNA and DNA.
DNA is the software of life, the molecules that pack all the genetic information of a cell. DNA and the genes within it are where mutations occur, enabling changes that create new species.
RNA is the close cousin to DNA. More accurately, RNA is thought to be a primitive ancestor of DNA.
RNA can't run a life form on its own, but 4 billion years ago it might have been on the verge of creating life, just needing some chemical fix to make the leap.
In today's world, RNA is dependent on DNA for performing its roles, which include coding for proteins.
If RNA is in fact the ancestor to DNA, then scientists have figured they could get RNA to replicate itself in a lab without the help of any proteins or other cellular machinery. Easy to say, hard to do.
But that's exactly what the Scripps researchers did. Then things went surprisingly further.
'Immortalized'
Specifically, the researchers synthesized RNA enzymes that can replicate themselves without the help of any proteins or other cellular components, and the process proceeds indefinitely.
"Immortalized" RNA, they call it, at least within the limited conditions of a laboratory.
More significantly, the scientists then mixed different RNA enzymes that had replicated, along with some of the raw material they were working with, and let them compete in what's sure to be the next big hit: "Survivor: Test Tube."
Remarkably, they bred.
And now and then, one of these survivors would screw up, binding with some other bit of raw material it hadn't been using. Hmm. That's exactly what life forms do ...
When these mutations occurred, "the resulting recombinant enzymes also were capable of sustained replication, with the most fit replicators growing in number to dominate the mixture," the scientists report.
The "creatures" — wait, we can't call them that! — evolved, with some "species" winning out.
"It kind of blew me away," said team member Tracey Lincoln of the Scripps Research Institute, who is working on her Ph.D. "What we have is non-living, but we've been able to show that it has some life-like properties, and that was extremely interesting."
Indeed.
Knocking on life's door
Lincoln's advisor, professor Gerald Joyce, reiterated that while the self-replicating RNA enzyme systems share certain characteristics of life, they are not life as we know it.
"What we've found could be relevant to how life begins, at that key moment when Darwinian evolution starts," Joyce said in a statement.
Joyce's restraint, clear also on an NPR report of the finding, has to be appreciated. He allows that some scientists familiar with the work have argued that this is life.
Another scientist said that what the researchers did is equivalent to recreating a scenario that might have led to the origin of life.
Joyce insists he and Lincoln have not created life: "We're knocking on that door," he says, "but of course we haven't achieved that."
Only when a system is developed in the lab that has the capability of evolving novel functions on its own can it be properly called life, Joyce said. In short, the molecules in Joyce's lab can't evolve any totally new tricks, he said.
Has Evolution Been Proven?
No, it has not been.
Many creationists would be content to end this essay there, but in reality, the situation is not so simple. To argue against the theory of evolution by saying that it "hasn't been proven" is to demonstrate a severe misunderstanding of the nature of science, which this essay will endeavor to correct.
It is true that the theory of evolution has not been proven - if, by that term, one means established beyond any further possibility of doubt or refutation. On the other hand, neither has atomic theory, the theory of relativity, quantum theory, or indeed any other theory in science. The reason for this is that science does not deal in absolute proof, only in the balance of the evidence.
To see why this is and must be true, imagine that we are scientists seeking to explain some feature of the natural world. Based on the evidence available to us, we can construct a hypothesis - an educated guess - which we offer as that explanation. If more evidence turns up that supports our hypothesis, if our hypothesis is testable and falsifiable, and if our hypothesis can be used to make predictions which turn out to be correct - if all these things are true, then our hypothesis graduates to the status of a theory and, in time, becomes accepted scientific wisdom.
But how do we really know the original hypothesis is true? What if it completely misses the mark, but gives the right answers just by coincidence? Or what if it is just an approximation, giving generally correct answers while failing to capture the true reality of what is going on? How can we ever be sure that these things are not the case?
The answer is, of course, that we cannot know this. This is why no scientific theory, including evolution, is ever considered to be proven. The more evidence that accumulates to support a theory, the more our confidence in it grows. Eventually, a point may be reached where the quantity of evidence supporting the theory is so vast, so overwhelming, that further attempts to deny or question it would be futile and unfounded. This is the case with the theory of evolution, as it is the case with the other theories, such as the atomic theory of matter or the theory of plate tectonics, that form the pillars of modern science. But this is not absolute proof. Not even the best-supported, most thoroughly verified theories of science are put on a pedestal and considered infallible, since at any time, some shocking new piece of evidence might turn up that completely contradicts accepted knowledge. We have no way of knowing that this will not happen in the future.
This is not to imply that the theory of evolution is in any way tentative or uncertain. On the contrary, it is extremely robust, backed by over a hundred years of research, experiment and observation. In all that time, not a single piece of evidence that seriously contradicts any part of it has ever turned up. Within the scientific community, evolution is not at all controversial and is no longer questioned; it is considered to be a fact, as simple and indisputable as gravity. While it can never be absolutely proven, it has come as close to attaining this status as it is possible for any scientific theory to be. To attack evolution by labeling it an "unproven theory" misses the point entirely. There is a saying in some scientific circles: "Proof is for mathematics and alcohol."
Survey: Americans switch faiths early, often
Religion Writer Eric Gorski, Ap Religion Writer
– Mon Apr 27, 12:45 pm ET
The U.S. is a nation of religious drifters, with about half of adults restlessly switching faith affiliation at least once during their lives, a new survey has found.
And the reasons behind all the swapping depend greatly on whether one grows up kneeling at Roman Catholic Mass, praying in a Protestant pew or occupied with nonreligious pursuits, according to a report issued Monday by the Pew Forum on Religion and Public Life.
While Catholics are more likely to leave the church because they stopped believing its teachings, many Protestants are driven to trade one Protestant denomination or affiliation for another because of changed life circumstances, the survey found.
The ranks of those unaffiliated with any religion, meanwhile, are growing not so much because of a lack of religious belief but because of disenchantment with religious leaders and institutions.
The report estimates that between 47 percent and 59 percent of U.S. adults have changed affiliation at least once. Most described just gradually drifting away from their childhood faith.
"This shows a sort of religion a la carte and how pervasive it is," said D. Michael Lindsay, a Rice University sociologist of religion. "In some ways, it's an indictment of organized Christianity. It suggests there's a big open door for newcomers, but a wide back door where people are leaving."
The report, "Faith in Flux: Changes in Religious Affiliation in the U.S.," sought to answer questions about widespread religion-changing identified in a 2007 Pew survey of 35,000 Americans.
The new report, based on re-interviews with more than 2,800 people from the original survey, focuses on religious populations that showed a lot of movement: ex-Catholics, ex-Protestants, Protestants who've swapped denominational families within Protestantism and people raised unaffiliated who now belong to a faith.
The 2007 survey estimated that 44 percent of U.S. adults had left their childhood religious affiliation.
But the re-interviews found the extent of religion-swapping is likely much greater. The new survey revealed that one in six Americans who belong to their childhood faith are "reverts" — people who left the faith, only to return later.
Roughly two-thirds of those raised Catholic or Protestant who now claim no religious affiliation say they have changed faiths at least twice. Thirty-two percent of unaffiliated ex-Protestants said they've changed three times or more.
Age is another factor. Most people who left their childhood faith did so before turning 24, and a majority joined their current religion before 36.
"If people want to see a truly free market at work, they really should look at the U.S. religious marketplace," said Luis Lugo, director of the Pew Forum on Religion and Public Life.
Sixteen percent of U.S. adults identified as unaffiliated in the 2007 survey; 7 percent of Americans described being raised unaffiliated, suggesting that many Americans end up leaving their religion for none.
About half of those who have become unaffiliated cited a belief that religious people are hypocritical, judgmental or insincere. Large numbers said they think religious organizations focus too much on rules, or that religious leaders are too focused on money and power.
John Green, a University of Akron political scientist and a senior fellow with the Pew Forum, classified most unaffiliated as "dissatisfied consumers." Only 4 percent identify as atheist or agnostic, and one-third say they just haven't found the right religion.
"A lot of the unaffiliated seem to be OK with religion in the abstract," Green said. "It's just the religion they were involved in bothered them or they disagreed with it."
The unaffiliated category is not just a destination. It's also a departure point: a slight majority of those raised unaffiliated eventually join a faith tradition.
Those who do cite several reasons: attraction of religious services and worship (74 percent), feeling unfulfilled spiritually (51 percent) or feeling called by God (55 percent).
The survey found that Catholicism has suffered the greatest net loss in all the religion switching. Nearly six in ten former Catholics who are now unaffiliated say they left Catholicism due to dissatisfaction with Catholic teachings on abortion and homosexuality. About half cited concerns about Catholic teachings on birth control and roughly four in ten named unhappiness with Catholicism's treatment of women.
Converts to evangelicalism were more likely to cite their belief that Catholicism didn't take the Bible literally enough, while mainline Protestants focused more on the treatment of women.
Fewer than three in 10 former Catholics cited the clergy sexual abuse scandal as a factor — a finding that Washington Archbishop Donald Wuerl cited as an example of the faith's resilience.
"Catholics can separate the sins and human failings of individuals from the substance of the faith," Wuerl said in a statement.
Wuerl noted a finding that getting teenagers to weekly Mass greatly improves their chances of staying in the fold; the same holds true for Protestant teens attending services.
The survey found that 15 percent of Americans were raised as Protestants but now belong to a different Protestant tradition than their upbringing. Nearly four in 10 cited a move to a new community, while one-third said they married someone from a different background.
What the Founding Father's Said
Benjamin Franklin
"Religious institutions that use the government power in support of themselves and force their views on persons of other faiths, or of no faith, undermine all our civil rights."
Thomas Jefferson, 1808 to the Virginia Baptists
"Christianity neither is, nor ever was, a part of the common law."
Thomas Jefferson, Feb 10th 1814
"Congress should not establish a religion, and enforce the legal observation of it by law, nor compel men to worship God in any manner contrary to their conscience."
James Madison
"The religion, then, of every man must be left to the conviction and conscience of every man; and that it is the right of every man…"
James Madison, June 20th 1785
"Is the appointment of Chaplains to the two houses of Congress consistent with the Constitution, and with the pure principle of religious freedom? In strictness the answer on both points must be in the negative."
James Madison


